Select Publications

Seefeld ML, Templeton EL, Lehtinen JM, Sinclair N, Yadav D, Hartwell BL. “Harnessing the potential of the NALT and BALT as targets for immunomodulation using engineering strategies to enhance mucosal uptake.” Front. Immunol. Sec. Mucosal Immunity. Volume 15 – 2024. DOI: 10.3389/fimmu.2024.1419527.

Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. “Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity.” Science Translational Medicine. 2022. DOI: 10.1126/scitranslmed.abn1413

Hartwell BL*, Martin JT*, Kumarapperuma S*, Melo MB, Carnathan DG, Cossette BJ, Adams J, Gong S, Zhang W, Tokatlian T, Menis S, Schiffner T, Franklin CG, Goins B, Fox PT, Silvestri G, Schief WR, Ruprecht RM, Irvine DJ. “Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates.” Biomaterials. 2021; 275:120868. DOI: 10.1016/j.biomaterials.2021.120868

Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen J, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li  N, Haupt S, Aung A, Cossette B, Kataria S, Bastidas R, Bhiman J, Linde C, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, and Irvine DJ. “A potent saponin and TLR agonist particulate vaccine adjuvant alters lymphatic flow and modulates B and T cell responses.” Science Immunology. 2021 Dec 3;6(66). DOI: 10.1126/sciimmunol.abf1152

Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru O, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. “Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.” Proc National Acad Sci. 2021; 118, e2106845118. DOI: 10.1073/pnas.2106845118

Hartwell BL, Pickens CJ, Leon M, Northrup L, Christopher MA, Griffin JD, Martinez-Becerra F, Berkland C. “Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis.” Journal of Autoimmunity. 2018; 93(9):76-88. DOI: 10.1016/j.jaut.2018.06.006

Hartwell BL, Pickens CJ, Leon M, Berkland C. “Multivalent antigen arrays exhibit high avidity binding and modulation of B cell receptor-mediated signaling to drive efficacy against experimental autoimmune encephalomyelitis.” Biomacromolecules. 2017; 18(6):1893-1907. DOI: 10.1021/acs.biomac.7b00335

Hartwell BL, Martinez-Becerra F, Chen J, Shinogle H, Sarnowski M, Moore D, Berkland C. “Antigen-specific binding of multivalent soluble antigen arrays induces receptor clustering and impedes B cell receptor mediated signaling.” Biomacromolecules. 2016; 17(3): 710-22. DOI: 10.1021/acs.biomac.5b01097

Hartwell BL, Smalter Hall A, Swafford D, Sullivan BP, Garza A, Sestak JO, Northrup L, Berkland C. “Molecular dynamics of multivalent soluble antigen arrays support two-signal codelivery mechanism in treatment of experimental autoimmune encephalomyelitis.” Molecular Pharmaceutics. 2016; 13(2): 330-43. DOI: 10.1021/acs.molpharmaceut.5b00825

Hartwell BL, Antunez L, Sullivan BP, Thati S, Sestak JO, Berkland C. “Multivalent nanomaterials: learning from vaccines and progressing to antigen-specific immunotherapies.” Journal of Pharmaceutical Science. 2015; 104(2): 346-61. Epub 2014. DOI: 10.1002/jps.24273